ACTG175: AIDS Clinical Trials Group Study 175
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ACTG175 R Documentation
AIDS Clinical Trials Group Study 175
Description
ACTG 175 was a randomized clinical trial to compare monotherapy with zidovudine or didanosine with
combination therapy with zidovudine and didanosine or zidovudine and zalcitabine in adults infected with the human
immunodeficiency virus type I whose CD4 T cell counts were between 200 and 500 per cubic millimeter.
Usage
data(ACTG175)
Format
A data frame with 2139 observations on the following 27 variables:
pidnumpatien ID number
ageage in years at baseline
wtkgweight in kg at baseline
hemohemophilia (0=no, 1=yes)
homohomosexual activity (0=no, 1=yes)
drugshistory of intravenous drug use (0=no, 1=yes)
karnofKarnofsky score (on a scale of 0-100)
opriornon-zidovudine antiretroviral therapy prior to initiation of study treatment (0=no, 1=yes)
z30zidovudine use in the 30 days prior to treatment initiation (0=no, 1=yes)
zpriorzidovudine use prior to treatment initiation (0=no, 1=yes)
preantinumber of days of previously received antiretroviral therapy
racerace (0=white, 1=non-white)
gendergender (0=female, 1=male)
str2antiretroviral history (0=naive, 1=experienced)
stratantiretroviral history stratification
(1='antiretroviral naive', 2='> 1 but <= 52 weeks of prior
antiretroviral therapy', 3='> 52 weeks')
symptomsymptomatic indicator (0=asymptomatic, 1=symptomatic)
treattreatment indicator (0=zidovudine only, 1=other therapies)
offtrtindicator of off-treatment before 96+/-5 weeks (0=no,1=yes)
cd40CD4 T cell count at baseline
cd420CD4 T cell count at 20+/-5 weeks
cd496CD4 T cell count at 96+/-5 weeks (=NA if missing)
rmissing CD4 T cell count at 96+/-5 weeks (0=missing, 1=observed)
cd80CD8 T cell count at baseline
cd820CD8 T cell count at 20+/-5 weeks
censindicator of observing the event in days
daysnumber of days until the first occurrence of: (i) a decline in CD4 T cell count of at least 50
(ii) an event indicating progression to AIDS, or (iii) death.
armstreatment arm (0=zidovudine, 1=zidovudine and didanosine, 2=zidovudine and zalcitabine,
3=didanosine).
Details
The variable days contains right-censored time-to-event
observations. The data set includes the following post-randomization
covariates: CD4 and CD8 T cell count at 20+/-5 weeks and the indicator
of whether or not the patient was taken off-treatment before
96+/-5 weeks.
References
Hammer SM, et al. (1996)
A trial comparing nucleoside monotherapy with combination therapy in
HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter.
New England Journal of Medicine 335, 1081-1090.
BART documentation built on June 22, 2024, 11:33 a.m.
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| ACTG175 | R Documentation |
AIDS Clinical Trials Group Study 175
Description
ACTG 175 was a randomized clinical trial to compare monotherapy with zidovudine or didanosine with combination therapy with zidovudine and didanosine or zidovudine and zalcitabine in adults infected with the human immunodeficiency virus type I whose CD4 T cell counts were between 200 and 500 per cubic millimeter.
Usage
data(ACTG175)Format
A data frame with 2139 observations on the following 27 variables:
pidnumpatien ID number
ageage in years at baseline
wtkgweight in kg at baseline
hemohemophilia (0=no, 1=yes)
homohomosexual activity (0=no, 1=yes)
drugshistory of intravenous drug use (0=no, 1=yes)
karnofKarnofsky score (on a scale of 0-100)
opriornon-zidovudine antiretroviral therapy prior to initiation of study treatment (0=no, 1=yes)
z30zidovudine use in the 30 days prior to treatment initiation (0=no, 1=yes)
zpriorzidovudine use prior to treatment initiation (0=no, 1=yes)
preantinumber of days of previously received antiretroviral therapy
racerace (0=white, 1=non-white)
gendergender (0=female, 1=male)
str2antiretroviral history (0=naive, 1=experienced)
stratantiretroviral history stratification (1='antiretroviral naive', 2='> 1 but <= 52 weeks of prior antiretroviral therapy', 3='> 52 weeks')
symptomsymptomatic indicator (0=asymptomatic, 1=symptomatic)
treattreatment indicator (0=zidovudine only, 1=other therapies)
offtrtindicator of off-treatment before 96+/-5 weeks (0=no,1=yes)
cd40CD4 T cell count at baseline
cd420CD4 T cell count at 20+/-5 weeks
cd496CD4 T cell count at 96+/-5 weeks (=
NAif missing)rmissing CD4 T cell count at 96+/-5 weeks (0=missing, 1=observed)
cd80CD8 T cell count at baseline
cd820CD8 T cell count at 20+/-5 weeks
censindicator of observing the event in
daysdaysnumber of days until the first occurrence of: (i) a decline in CD4 T cell count of at least 50 (ii) an event indicating progression to AIDS, or (iii) death.
armstreatment arm (0=zidovudine, 1=zidovudine and didanosine, 2=zidovudine and zalcitabine, 3=didanosine).
Details
The variable days contains right-censored time-to-event
observations. The data set includes the following post-randomization
covariates: CD4 and CD8 T cell count at 20+/-5 weeks and the indicator
of whether or not the patient was taken off-treatment before
96+/-5 weeks.
References
Hammer SM, et al. (1996) A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. New England Journal of Medicine 335, 1081-1090.
R Package Documentation
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We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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