gehan: Times of Remission of Leukemia Patients (Gehan)

In BGPhazard: Markov Beta and Gamma Processes for Modeling Hazard Rates

Description Usage Format Source References Examples

Description

Freireich et al. (1963) report the results of a clinical trial of a drug 6-mercaptopurine (6-MP) versus a placebo (control) in 42 children with acute leukemia. The trial was conducted at 11 American hospitals. The trial was conducted by matching pairs of patients at a given hospital by remission status (complete or partial) and randomizing within the pair to either a 6-MP or placebo maintenance therapy. Patients were followed until their leukemia returned (relapse) or until the end of the study (in weeks). The data was taken from Klein & Moeschberger (2003) and is contained in the MASS package.

Usage

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data(gehan)

Format

A data frame with 42 observations containing:

pair

Pair index.

time

Remission time (weeks).

cens

Status: 0=censored.

treat

Treatment: control or 6-MP.

Source

Klein, J. P., & Moeschberger, M. L. (2003). Survival analysis: techniques for censored and truncated data. Springer Science & Business Media.

References

Freireich, E. J., et al. (1963). The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: A model for evaluation of other potentially useful therapy. Blood, 21(6), 699-716.

Examples

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## Gamma Process Example 1 
#  data(gehan)
#  timesG <- gehan$time[gehan$treat == "6-MP"]
#  deltaG <- gehan$cens[gehan$treat == "6-MP"]
#  GEX1 <- GaMRes(timesG, deltaG, K = 8, iterations = 3000)
#  GaPloth(GEX1, confint = FALSE)
#  GaPloth(GEX1, fun = "both", confint = TRUE)