Times of Remission of Leukemia Patients (Gehan)
Freireich et al. (1963) report the results of a clinical trial of a drug 6-mercaptopurine (6-MP) versus a placebo (control) in 42 children with acute leukemia. The trial was conducted at 11 American hospitals. The trial was conducted by matching pairs of patients at a given hospital by remission status (complete or partial) and randomizing within the pair to either a 6-MP or placebo maintenance therapy. Patients were followed until their leukemia returned (relapse) or until the end of the study (in weeks). The data was taken from Klein & Moeschberger (2003) and is contained in the
A data frame with 42 observations containing:
Remission time (weeks).
Treatment: control or 6-MP.
Klein, J. P., & Moeschberger, M. L. (2003). Survival analysis: techniques for censored and truncated data. Springer Science & Business Media.
Freireich, E. J., et al. (1963). The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: A model for evaluation of other potentially useful therapy. Blood, 21(6), 699-716.
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## Gamma Process Example 1 # data(gehan) # timesG <- gehan$time[gehan$treat == "6-MP"] # deltaG <- gehan$cens[gehan$treat == "6-MP"] # GEX1 <- GaMRes(timesG, deltaG, K = 8, iterations = 3000) # GaPloth(GEX1, confint = FALSE) # GaPloth(GEX1, fun = "both", confint = TRUE)