Prognostic Enrichment is a strategy of enriching a clinical trial for testing an intervention intended to prevent or delay an unwanted clinical event. A prognostically enriched trial enrolls only patients who are more likely to experience the unwanted clinical event than the broader patient population (R. Temple (2010) <doi:10.1038/clpt.2010.233>). By testing the intervention in an enriched study population, the trial may be adequately powered with a smaller sample size, which can have both practical and ethical advantages. This package provides tools to evaluate biomarkers for prognostic enrichment of clinical trials with survival/time-to-event outcomes.
Package details |
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Author | Si Cheng [cre, aut], Kathleen F. Kerr [ctb] |
Maintainer | Si Cheng <chengsi@uw.edu> |
License | GPL (>= 2) |
Version | 0.1.0 |
Package repository | View on CRAN |
Installation |
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