Prognostic Enrichment is a strategy of enriching a clinical trial for testing an intervention intended to prevent or delay an unwanted clinical event. A prognostically enriched trial enrolls only patients who are more likely to experience the unwanted clinical event than the broader patient population (R. Temple (2010) <doi:10.1038/clpt.2010.233>). By testing the intervention in an enriched study population, the trial may be adequately powered with a smaller sample size, which can have both practical and ethical advantages. This package provides tools to evaluate biomarkers for prognostic enrichment of clinical trials with survival/time-to-event outcomes.
|Author||Si Cheng [cre, aut], Kathleen F. Kerr [ctb]|
|Maintainer||Si Cheng <firstname.lastname@example.org>|
|License||GPL (>= 2)|
|Package repository||View on CRAN|
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