Conditional Power (Exponential)

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Description

Calculates the conditional power within the exponential model.

Usage

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 ConPwrExp(data, cont.time, new.pat = c(0, 0),
           theta.0 = 1, alpha = 0.05,
           disp.data = FALSE, plot.km = FALSE)

Arguments

data

Data frame which consists of at least three columns with the group (two different expressions) in the first, status (1 = event, 0 = censored) in the second and event time in the third column.

cont.time

Period of time of continuing the trial.

new.pat

2-dimensional vector which consists of numbers of new patients who will be recruited each time unit (first component = group 1, second component = group 2) with default at (0, 0).

theta.0

Originally postulated clinically relevant difference (hazard ratio = hazard of group 2 / hazard of group 1) with default at 1.

alpha

Significance level for conditional power calculations with default at 0.05.

disp.data

Logical value indicating if all calculated data should be displayed with default at FALSE.

plot.km

Logical value indicating if Kaplan-Meier curves and estimated survival curves according to the exponential model should be plotted with default at FALSE.

Details

This function calculates the conditional power within the exponential model, i. e.

S(t) = e^(- λ t)

for all t ≥ 0 and λ > 0, and plots the conditional power curve.

Optionally, further data will be displayed. This includes data from interim analysis, log-likelihoods, AICs, calculated estimators and further patient times.

Moreover, it is possible to plot the Kaplan-Meier curves and the estimated survival curves according to the exponential model.

Value

See Details.

Returns a list which consists of the following components:

lambda1.hat

estimated hazard of group 1

lambda2.hat

estimated hazard of group 2

theta.hat

estimated hazard ratio = estimated hazard of group 2 / estimated hazard of group 1

gamma.theta.0

conditional power

Note

There are several mechanisms to ensure that no illegal operations will be done. That is why there should not be too less data in the data frame, for example one patient of each group and both being censored.

Author(s)

Andreas Kuehnapfel

References

Kuehnapfel, A. (2013). Die bedingte Power in der Ueberlebenszeitanalyse.

See Also

CP
GenerateDataFrame
test

Examples

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 # data frame 'test' generated by 'GenerateDataFrame'
 
 # conditional power calculations
 # within the exponential model
 ConPwrExp(data = test, cont.time = 12, new.pat = c(2.5, 2.5),
           theta.0 = 0.75, alpha = 0.05,
           disp.data = TRUE, plot.km = TRUE)

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