RunProfilePertubation: Execute an NLME profile perturbation

In Certara.RsNLME: Pharmacometric Modeling

Execute an NLME profile perturbation

Description

Execute an NLME profile perturbation

Usage

RunProfilePertubation(
  hostPlatform,
  dataset,
  params,
  profiles,
  sortColumns,
  scenarios = list(),
  runInBackground = FALSE,
  workingDir = NULL
)

Arguments

hostPlatform	How to execute the run(NlmeParallelHost)
dataset	Dataset and model information(NlmeDataset)
params	Engine parameters(NlmeEngineExtraParams)
profiles	Profiles to perturbate(ProfileParameters)
sortColumns	Optional list of columns to sort and fit(SortColumns)
scenarios	Optional list of scenarios to fit(NlmeScenario)
runInBackground	TRUE will run in background and return prompt(Bool)
workingDir	Directory in which to run the job. Current working directory is used if NULL

Value

Object of class ProfileNlmeJob

Examples

  dataset <- NlmeDataset()

  params <- NlmeEngineExtraParams(
    method = 3,
    num_iterations = 1000
  )
  host <- hostParams(parallelMethod = "None",
                    hostName = "local",
                    numCores = 1)
  sortColumns <- SortColumns("")
  profile1 <- ProfileVar("tvV", 9.548, "-2,-1,0,1,2")
  profile2 <- ProfileVar("tvCl", 0.919, "-0.5,0,1.5")
  profiles <- ProfileParameters("USE_DELTA", c(profile1, profile2))
  # dataFile, colDefFile, modelFile are assumed to be written to the working directory
  job <- RunProfilePertubation(host, dataset, params, profiles, sortColumns, scenarios)

Certara.RsNLME documentation built on April 3, 2025, 11:04 p.m.