pkcovbqlData: Pharmacokinetic pediatric dataset containing 80 subjects with...

In Certara.RsNLME: Pharmacometric Modeling

Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose.

Description

Pharmacokinetic pediatric dataset containing 80 subjects with single bolus dose. Dataset includes covariates and observations Below Quantification Limit (BQL).

Usage

pkcovbqlData

Format

A data frame with 880 rows and 8 variables:

ID

Subject ID

Time

Nominal Time

Dose

Amount of dose

CObs

Observations of drug concentration in blood

LLOQ

Lower Limit of Quantification

CObsBQL

Variable that indicates whether the observed drug concentration is below the limit of quantification

BW

Body weight

PMA

Postmenstrual age

Source

The data is simulated using a one-compartment model with IV bolus, where the central volume is allometric weight scaled, and the clearance is scaled by a combination of allometric weight scaling and a sigmoidal maturation function driven by PMA. Germovsek E., et al, Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance, Clin Pharmacokinet (2019) 58:39–52.

Certara.RsNLME documentation built on April 3, 2025, 11:04 p.m.