profilePertubate: Executes an NLME profile perturbation

In Certara.RsNLME: Pharmacometric Modeling

Executes an NLME profile perturbation

Description

Executes an NLME profile perturbation

Usage

profilePertubate(
  hostPlatform,
  params = NULL,
  profiles,
  model = NULL,
  sortColumns = SortColumns(""),
  scenarios = list(),
  runInBackground = FALSE
)

Arguments

hostPlatform	How to execute the run(NlmeParallelHost)
params	Engine parameters(NlmeEngineExtraParams)
profiles	Profiles to perturbate(ProfileParameters)
model	PK/PD model
sortColumns	Optional list of columns to sort and fit(SortColumns)
scenarios	Optional list of scenarios to fit(NlmeScenario)
runInBackground	Set to TRUE to run in background and return prompt(Bool)

Value

List of results from NLME execution.

Examples

# metod = 3 is FOCE-LB
 params <- NlmeEngineExtraParams(
   method = 3,
   numIterations = 1000
 )

 profile1 <- ProfileVar("tvV", 9.548, "-2,-1,0,1,2")
 profile2 <- ProfileVar("tvCl", 0.919, "-0.5,0,1.5")
 profiles <- ProfileParameters("USE_DELTA", c(profile1, profile2))

 job <- profilePertubate(defaultHost, params, profiles, model)

Certara.RsNLME documentation built on April 3, 2025, 11:04 p.m.