randomEffect: Sets or updates the covariance matrix of random effects

In Certara.RsNLME: Pharmacometric Modeling

Sets or updates the covariance matrix of random effects

Description

Use to set or update the covariance matrix of random effects in a model object.

Usage

randomEffect(
  .Object,
  effect,
  value = NULL,
  isDiagonal = TRUE,
  isFrozen = FALSE,
  ...
)

Arguments

.Object	Model object
effect	One or more names of available random effects.
value	Initial values for the diagonal elements of the covariance matrix of random effects (if isDiagonal = TRUE, or initial values for the lower triangular elements (including diagonal elements) of the covariance matrix (if isDiagonal = FALSE) in a row-wise order.
isDiagonal	Set to TRUE to if the covariance matrix of the specified random effects is a diagonal matrix. or FALSE if not.
isFrozen	Set to TRUE to freeze the covariance matrix of random effects.
...	Additional arguments

Value

Modified NlmePmlModel object

Examples

model <- pkmodel(
  numCompartments = 2,
  data = pkData,
  ID = "Subject",
  Time = "Act_Time",
  A1 = "Amount",
  CObs = "Conc",
  modelName = "TwCpt_IVBolus_FOCE_ELS"
  )

model <- model |>
  randomEffect(effect = c("nV", "nCl", "nCl2"), value = rep(0.1, 3))

Certara.RsNLME documentation built on April 3, 2025, 11:04 p.m.