Developmental toxicology study of DEHP in mice
This data set is based on a National Toxicology Program study on diethylhexyl phthalate, DEHP. Pregnant CD-1 mice were randomly assigned to receive 0, 250, 500, 1000, or 1500 ppm of DEHP in their feed during gestational days 0-17. The uterine contents of the mice were examined for toxicity endpoints prior to normal delivery. The possible outcomes are 1) malformation, 2) death or resorption, 3) no adverse event.
A 'CMData' object, that is a data frame with the following variables
|Trt||factor giving treatment group|
|ClusterSize||the size of the litter|
|NResp.1||the number of fetuses with a type 1 outcome (malformation)|
|NResp.2||the number of fetuses with a type 2 outcome (death or resorption)|
|NResp.3||the number of fetuses with a type 3 outcome (normal)|
|Freq||the number of litters with the given ClusterSize/NResp.1-NResp.3 combination|
National Toxicology Program, NTP Study TER84064.
Tyl, R. W., Price, C. J., Marr, M. C., and Kimmel, C. A. (1988). Developmental toxicity evaluation of dietary di(2-ethylhexy)phthalate in Fischer 344 rats and CD-1 mice. Fundamental and Applied Toxicology 10, 395-412.
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