Developmental toxicology study of DEHP in mice

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Description

This data set is based on a National Toxicology Program study on diethylhexyl phthalate, DEHP. Pregnant CD-1 mice were randomly assigned to receive 0, 250, 500, 1000, or 1500 ppm of DEHP in their feed during gestational days 0-17. The uterine contents of the mice were examined for toxicity endpoints prior to normal delivery. The possible outcomes are 1) malformation, 2) death or resorption, 3) no adverse event.

Usage

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Format

A 'CMData' object, that is a data frame with the following variables

Trt factor giving treatment group
ClusterSize the size of the litter
NResp.1 the number of fetuses with a type 1 outcome (malformation)
NResp.2 the number of fetuses with a type 2 outcome (death or resorption)
NResp.3 the number of fetuses with a type 3 outcome (normal)
Freq the number of litters with the given ClusterSize/NResp.1-NResp.3 combination

Source

National Toxicology Program, NTP Study TER84064.

References

Tyl, R. W., Price, C. J., Marr, M. C., and Kimmel, C. A. (1988). Developmental toxicity evaluation of dietary di(2-ethylhexy)phthalate in Fischer 344 rats and CD-1 mice. Fundamental and Applied Toxicology 10, 395-412.

Examples

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data(dehp)
library(lattice)
pl <- xyplot(NResp.1/ClusterSize + NResp.2/ClusterSize + NResp.3/ClusterSize ~ Trt, 
        data=dehp, outer=TRUE, type=c("p","a"), jitter.x=TRUE)
pl$condlevels[[1]] <- c("Malformed", "Dead", "Normal")
print(pl)

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