Filter CpGs based on Intra-class Correlation Coefficients (ICCs) when replicates are available. ICCs are calculated by fitting linear mixed effects models to all samples including the un-replicated samples. Including the large number of un-replicated samples improves ICC estimates dramatically. The method accommodates any replicate design.
|Author||Jun Chen <[email protected]>|
|Date of publication||2017-08-23 22:09:07 UTC|
|Maintainer||Jun Chen <[email protected]>|
|Package repository||View on CRAN|
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