gaba: Effect of pentazocine on post-operative pain (average VAS...
| gaba | R Documentation |
Effect of pentazocine on post-operative pain (average VAS scores)
Description
The table shows, separately for males and females, the effect of pentazocine on post-operative pain profiles (average VAS scores), with (mbac and fbac) and without (mpl and fpl) preoperatively administered baclofen. Pain scores are recorded every 20 minutes, from 10 minutes to 170 minutes.
Usage
gabaFormat
A data frame with 9 observations on the following 7 variables.
mina numeric vector
mbaca numeric vector
mpla numeric vector
fbaca numeric vector
fpla numeric vector
avbaca numeric vector
avplaca numeric vector
Details
15 females were given baclofen, as against 3 males. 7 females received the placebo, as against 16 males. Averages for the two treatments (baclofen/placebo), taken over all trial participants and ignoring sex, are misleading.
Source
Gordon, N. C. et al.(1995): 'Enhancement of Morphine Analgesia
by the GABA_B against Baclofen'. Neuroscience 69: 345-349.
Examples
data(gaba)
mr <- range(gaba$min)
tran <- range(gaba[, c("mbac","mpl","fbac","fpl")])
## Means by treatment and sex
par(mfrow=c(1,2))
plot(mr, tran, xlab = "Time post pentazocine (min)",
ylab = "Reduction in VAS pain rating",
type = "n", xlim = c(0, 170), ylim = tran)
points(gaba$min, gaba$fbac, pch = 1, col = 8, lwd = 2, lty = 2,
type = "b")
points(gaba$min, gaba$fpl, pch = 0, col = 8, lwd = 2, lty = 2,
type = "b")
points(gaba$min, gaba$mbac, pch = 16, col = 8, lty = 2, type = "b")
points(gaba$min, gaba$mpl, pch = 15, col = 8, lty = 2, type = "b")
box()
## Now plot means, by treatment, averaged over all participants
plot(mr, tran, xlab = "Time post pentazocine (min)",
ylab = "Reduction in VAS pain rating",
type = "n", xlim = c(0, 170), ylim = tran)
bac <- (15 * gaba$fbac + 3 * gaba$mbac)/18
plac <- (7 * gaba$fpl + 9 * gaba$mpl)/16
points(gaba$min, plac, pch = 15, lty = 1, col=1, type = "b")
points(gaba$min, bac, pch = 16, lty = 1, col=1, type = "b")
box()
par(mfrow=c(1,1))
