DAFOT: Detector of Active Flow on a Tree

Quantitative comparison of microbial composition from different populations is a fundamental task in various microbiome studies. The main goal of this package is to provide a new method for two-sample testing for microbial compositional data by leveraging the phylogenetic tree information. Empirical evidence from real data sets suggests that the phylogenetic microbial composition difference between two populations is usually sparse. Motivated by this observation, this package implements a new maximum type test, Detector of Active Flow on a Tree (DAFOT). It is shown that DAFOT is particularly powerful against sparse phylogenetic composition difference and enjoys certain optimality. Chen, J., Bittinger, K., Charlson, E. S., Hoffmann, C., Lewis, J., Wu, G. D., Collman, R. G., Bushman, F. D., Li, H. (2012) <doi:10.1093/bioinformatics/bts342>.

Getting started

Package details

AuthorShulei Wang, T. Tony Cai and Hongzhe Li
MaintainerShulei Wang <Shulei.Wang@pennmedicine.upenn.edu>
LicenseMIT+file LICENSE
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:

Try the DAFOT package in your browser

Any scripts or data that you put into this service are public.

DAFOT documentation built on Oct. 9, 2019, 5:04 p.m.