Description Usage Arguments Details Value Author(s) References Examples
Implementation of the algorithm presented in Par. 10.3.3 of Wellek S (2010) Testing statistical hypotheses of equivalence and noninferiority. Second edition.
1 | po_pbibe(n,eps,pio,zq,s,tol,sw,ihmax)
|
n |
sample size |
eps |
equivalence margin to an individual log-bioavailability ratio |
pio |
prespecified lower bound to the probability of obtaining an individual log-bioavailability ratio falling in the equivalence range (-\varepsilon,\varepsilon) |
zq |
mean log-bioavailability ratio observed in the sample under analysis |
s |
square root of the sample variance of the log-bioavailability ratios |
tol |
maximum numerical error allowed for transforming the hypothesis of PBIBE into a region in the parameter space of the log-normal distribution assumed to underlie the given sample of individual bioavailability ratios |
sw |
step width used in the numerical procedure yielding results at a level of accuracy specified by the value chosen for tol |
ihmax |
maximum number of interval halving steps to be carried out in finding the region specified in the parameter space according to the criterion of PBIBE |
The program uses 96-point Gauss-Legendre quadrature.
n |
sample size |
eps |
equivalence margin to an individual log-bioavailability ratio |
pio |
prespecified lower bound to the probability of obtaining an individual log-bioavailability ratio falling in the equivalence range (-\varepsilon,\varepsilon) |
zq |
mean log-bioavailability ratio observed in the sample under analysis |
s |
square root of the sample variance of the log-bioavailability ratios |
tol |
maximum numerical error allowed for transforming the hypothesis of PBIBE into a region in the parameter space of the log-normal distribution assumed to underlie the given sample of individual bioavailability ratios |
sw |
step width used in the numerical procedure yielding results at a level of accuracy specified by the value chosen for tol |
ihmax |
maximum number of interval halving steps to be carried out in finding the region specified in the parameter space according to the criterion of PBIBE |
PO_PBIBE |
posterior probability of the alternative hypothesis of PBIBE |
Stefan Wellek <stefan.wellek@zi-mannheim.de>
Peter Ziegler <peter.ziegler@zi-mannheim.de>
Wellek S: Bayesian construction of an improved parametric test for probability-based individual bioequivalence. Biometrical Journal 42 (2000), 1039-52.
Wellek S: Testing statistical hypotheses of equivalence and noninferiority. Second edition. Boca Raton: Chapman & Hall/CRC Press, 2010, Par. 10.3.3.
1 | po_pbibe(20,0.25,0.75,0.17451,0.04169, 10e-10,0.01,100)
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