FBCRMSimTrial: Provides simulation results using FBCRM

In FBCRM: Phase I Optimal Dose Assignment using the FBCRM and MFBCRM Methods

Provides simulation results using FBCRM

Description

Provides simulation results using FBCRM

Usage

FBCRMSimTrial(max_samp, Cohort, ptrue, mu, p_rho, sigma, mtd, p_u, B, M)

Arguments

max_samp	Total number of patients recruited/will be recruited in the trial.
Cohort	Number of patients within each cohort.
ptrue	True toxicity probability vector.
mu	Prior expected toxicity probability at each dose.
p_rho	Prior probability that two dose-toxicity probabilities will not cluster together.
sigma	Prior standard deviation for the parameter alpha.
mtd	Maximum Tolerated dose toxicity probability (pre defined).
p_u	Cut-off toxicity probability for first dose.
B	Number of Iterations to run for MCMC.
M	Number of simulations to run.

Value

A list containing (1) Design parameters and prior hyperparameters used for simulating the trials and (2) a summary of the trial simulation results including the percent of times each dose was selected and the average number of toxicities seen in the trial.

Examples

max_samp=15
Cohort=3
ptrue=c(0.01,0.05,0.15,0.3,0.45,0.5,0.6,0.8)
mu=seq(0.1,0.8,0.1)
p_rho=0.9
sigma = 2
mtd = 0.3
p_u=0.9
B=200 ##Number of iterations, Change to 2k
M=10 ##Number of simulations, Change to larger
Z=FBCRMSimTrial(max_samp,Cohort,ptrue,mu,p_rho,sigma,mtd,p_u,B,M)
Z

FBCRM documentation built on Oct. 29, 2022, 9:05 a.m.