fdr.power.alpha | R Documentation |
Compute the FDR for given values of the p-value threshold alpha, average power, and proportion pi0 of tests with a true null hypothesis.
fdr.power.alpha(alpha, pwr, pi0, method = "HH")
alpha |
p-value threshold (vector) |
pwr |
average power |
pi0 |
actual proportion of tests with a true null hypothesis |
method |
method to estimate proportion |
FDR
Pounds S and Cheng C, "Sample size determination for the false discovery rate." Bioinformatics 21.23 (2005): 4263-4271.
Gadbury GL, et al. (2004) Power and sample size estimation in high dimensional biology. Statistical Methods in Medical Research 13(4):325-38.
Jung,Sin-Ho."Sample size for FDR-control in microarray data analysis." Bioinformatics 21.14 (2005): 3097-3104.
Ni Y, Seffernick A, Onar-Thomas A, Pounds S. "Computing Power and Sample Size for the False Discovery Rate in Multiple Applications", Manuscript.
alpha = 1:100/1000;
pwr = rep(0.8,length(alpha));
pi0 = 0.95;
fdr.power.alpha(alpha,pwr,pi0,method="HH")
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