Description Details Author(s) References Examples
The Gaussian graphical model is a widely used tool for learning gene regulatory networks with high-dimensional gene expression data. For many real problems, the data are heterogeneous, which may contain some subgroups or come from different resources. This package provide a Gaussian Graphical Mixture Model (GGMM) for the heterogeneous data.
Package: | GGMM |
Type: | Package |
Version: | 1.0.1 |
Date: | 2019-03-17 |
License: | GPL-2 |
This package illustrates the use of the Gaussian Graphical Mixture Model in two parts:
The first part is to apply the GGMM to estimate network structures using high-dimensional heterogeneous data with a simulated dataset SimHetDat(n,p,...)
and our proposed method GGMM(data,...)
.
The second part is to apply the GGMM to learn a real data example BRGM(breast,...)
, i.e. to learn a common gene regulatory network with heterogeneous gene expression data of breast cancer. The real data example are from The Cancer Genome Atlas (TCGA) with code data(breast)
.
Bochao Jia, Faming Liang Maintainer: Bochao Jia<jbc409@ufl.edu>
Liang, F., Song, Q. and Qiu, P. (2015). An Equivalent Measure of Partial Correlation Coefficients for High Dimensional Gaussian Graphical Models. J. Amer. Statist. Assoc., 110, 1248-1265.<doi:10.1080/01621459.2015.1012391>
Liang, F. and Zhang, J. (2008) Estimating FDR under general dependence using stochastic approximation. Biometrika, 95(4), 961-977.<doi:10.1093/biomet/asn036>
Liang, F., Jia, B., Xue, J., Li, Q., and Luo, Y. (2018). An Imputation Regularized Optimization Algorithm for High-Dimensional Missing Data Problems and Beyond. Submitted to Journal of the Royal Statistical Society Series B. <arXiv:1802.02251>
Jia, B., Xu, S., Xiao, G., Lamba, V., Liang, F. (2017) Inference of Genetic Networks from Next Generation Sequencing Data. Biometrics.
Jia, B. and Liang, F. (2018). Learning Gene Regulatory Networks with High-Dimensional Heterogeneous Data. Accept by ICSA Springer Book. <arXiv:1805.02547>
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