GMMAT: Generalized Linear Mixed Model Association Tests

Perform association tests using generalized linear mixed models (GLMMs) in genome-wide association studies (GWAS) and sequencing association studies. First, GMMAT fits a GLMM with covariate adjustment and random effects to account for population structure and familial or cryptic relatedness. For GWAS, GMMAT performs score tests for each genetic variant as proposed in Chen et al. (2016) <DOI:10.1016/j.ajhg.2016.02.012>. For candidate gene studies, GMMAT can also perform Wald tests to get the effect size estimate for each genetic variant. For rare variant analysis from sequencing association studies, GMMAT performs the variant Set Mixed Model Association Tests (SMMAT) as proposed in Chen et al. (2019) <DOI:10.1016/j.ajhg.2018.12.012>, including the burden test, the sequence kernel association test (SKAT), SKAT-O and an efficient hybrid test of the burden test and SKAT, based on user-defined variant sets.

Package details

AuthorHan Chen, Matthew P. Conomos, Duy T. Pham
MaintainerHan Chen <Han.Chen.2@uth.tmc.edu>
LicenseGPL-3
Version1.3.2
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("GMMAT")

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GMMAT documentation built on July 16, 2021, 9:09 a.m.