get.ts.bin.int.oc: Get two sample binary interim OC

In GNGTools: Tools for Go/No-Go Decision-Making Framework

Get two sample binary interim OC

Description

Get two sample binary interim OC

Usage

get.ts.bin.int.oc(
  a.con = 1,
  b.con = 1,
  a.trt = 1,
  b.trt = 1,
  Delta.tv = 0.3,
  Delta.lrv = 0.2,
  tau.tv = 0.1,
  tau.lrv = 0.8,
  tau.ng = 0.65,
  go.thresh = 0.8,
  ng.thresh = 0.8,
  n.con = 40,
  n.trt = 40,
  n.int.c = c(10, 20, 30),
  n.int.t = c(10, 20, 30),
  DecisionTable = NULL,
  runs = 500,
  ControlRate = 0.2,
  TreatmentEffect = seq(0, 0.8, 0.1),
  include_nogo = TRUE
)

Arguments

a.con	alpha parameter for control
b.con	beta parameter for control
a.trt	alpha parameter for treatment
b.trt	beta parameter for treatment
Delta.tv	Base TPP
Delta.lrv	min TPP
tau.tv	study-end threshold for Base TPP
tau.lrv	study-end threshold for Min TPP
tau.ng	study-end threshold for NG
go.thresh	threshold for predictive probabilities at interim
ng.thresh	threshold for predictive probabilities at interim
n.con	final sample size for control
n.trt	final sample size for treatment
n.int.c	interim sample sizes for control
n.int.t	interim sample sizes for treatment
DecisionTable	results from get.ts.bin.int.dec
runs	number of simulation runs
ControlRate	assumed rate in the control group
TreatmentEffect	vector of treatment effects relative to control group.
include_nogo	logical

Value

dataframe of simulation results with the following columns: * **Effect** the difference between the control Rate and treatment rate. (TreatmentRate = ControlRate + Effect) * **run** the grouping variable by run. * **assessment** the assessment in order, the last assessment is the final analysis results. * **TreatmentEffect** The true response rate for the treatment group. (ControlRate is the same for all runs, it is not in the output, only the function input. We may want to change this for completeness, or include it in Param) * **TotalResponse** for control (_C) and treatment(_T) respectively the total number of responses observed at that particular assessment. This is the cumulative sum over the assessments. * **Decision** The decision at the assessment given the total response up to that point. Note that the decision is calculated differently depending the assessment, the last assessment uses final assessment calculation while the earlier assessments use the interim assessment calculations.

Examples

my.ts.bin.int.oc <-  get.ts.bin.int.oc()
head(my.ts.bin.int.oc)

GNGTools documentation built on Dec. 16, 2022, 5:09 p.m.