GSSE: Genotype-Specific Survival Estimation

We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.

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AuthorBaosheng Liang, Yuanjia Wang and Donglin Zeng
Date of publication2015-10-20 08:06:35
MaintainerBaosheng Liang <>
LicenseGPL (>= 2)

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