Description Usage Arguments Details Value References Examples
Pooling input p-values and perfrom FDR adjustments
1 | ppool(pmat, method = "SD")
|
pmat |
p-values matrix stored by columns |
method |
pooling methods, see details |
for p-values poolings, we provided six methods. "FI" for Fisher's method, "FD" for Fisher's with correlation adjustments, "SI" for Stouffer's method, "SD" for Stouffer's method with correlation adjustments, "MI" for minimum p-value methods, and "MA" for maximum p-value method
stat |
pooled test statistcs |
pvalue |
pooled p-values |
adjp |
pooled p-values via "BH" adjustments |
Benjamini, Y. and Y. Hochberg (1995). "Controlling the false discovery rate: a practical and powerful approach to multiple testing." Journal of the Royal Statistical Society. Series B (Methodological): 289-300.
Chang, L.-C., et al. (2013). "Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline." BMC bioinformatics 14(1): 368.
Won, S., et al. (2009). "Choosing an optimal method to combine P-values." Statistics in medicine 28(11): 1537-1553.
Alves, G., & Yu, Y. K. (2014). Accuracy evaluation of the unified P-value from combining correlated P-values. PloS one, 9(3), e91225.
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