LTFHPlus-package: LTFHPlus: Implementation of LT-FH++

In LTFHPlus: Implementation of LT-FH++

LTFHPlus: Implementation of LT-FH++

Description

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/j.ajhg.2022.01.009")} as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1038/s41467-023-41210-z")} as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

Author(s)

Maintainer: Emil Michael Pedersen [e-mail]

Authors:

• Florian Privé [e-mail] [thesis advisor]

• Jette Steinbach [e-mail]

Other contributors:

• Bjarni Jóhann Vilhjálmsson [e-mail] [thesis advisor]

• Esben Agerbo [e-mail] [thesis advisor]

• Lucas Rasmussen [e-mail] [contributor]

See Also

Useful links:

• https://github.com/EmilMiP/LTFHPlus

• Report bugs at https://github.com/EmilMiP/LTFHPlus/issues

LTFHPlus documentation built on April 12, 2025, 1:38 a.m.