Get_UV_from_varU: Compute the summary statistics given the score statistics and...

In MTAR: Multi-Trait Analysis of Rare-Variant Association Study

Description

This function allows you to calculate the score summary statistics U and their covariance matrix V for MTAR, given the score summary statistics and their variance.

Usage

Get_UV_from_varU(U, varU, R)

Arguments

U	a numeric list, each sublist containing score summary statistics U for each study. In each study, a numeric m \times K matrix with each row as a SNP and each column as a separate trait. The number of traits and the number of SNPs in each study can be different but their names are required.
varU	a numeric list, each sublist containing the variance of score summary statistics information for each study. In each study, a numeric m \times K matrix with each row as a SNP and each column as a separate trait.
R	a SNP correlation matrix, which should contain the correlation of all the SNPs in these studies.

Value

A list containing summary statistics for each traits, the score summary statistics U and their covariance matrix V.

Author(s)

Lan Luo

Examples

data("varU.example")
attach(varU.example)
obs.stat <- Get_UV_from_varU(U = U, varU = varU, R= R)
obs.stat
detach(varU.example)

MTAR documentation built on April 23, 2020, 1:05 a.m.