MetProc: Separate Metabolites into Likely Measurement Artifacts and True Metabolites

Split an untargeted metabolomics data set into a set of likely true metabolites and a set of likely measurement artifacts. This process involves comparing missing rates of pooled plasma samples and biological samples. The functions assume a fixed injection order of samples where biological samples are randomized and processed between intermittent pooled plasma samples. By comparing patterns of missing data across injection order, metabolites that appear in blocks and are likely artifacts can be separated from metabolites that seem to have random dispersion of missing data. The two main metrics used are: 1. the number of consecutive blocks of samples with present data and 2. the correlation of missing rates between biological samples and flanking pooled plasma samples.

AuthorMark Chaffin
Date of publication2016-05-19 05:46:39
MaintainerMark Chaffin <mac8278@mail.harvard.edu>
LicenseGPL (>= 2)
Version1.0.1

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Files in this package

MetProc
MetProc/inst
MetProc/inst/extdata
MetProc/inst/extdata/sampledata.csv
MetProc/inst/doc
MetProc/inst/doc/using-MetProc.html
MetProc/inst/doc/using-MetProc.R
MetProc/inst/doc/using-MetProc.Rmd
MetProc/NAMESPACE
MetProc/R
MetProc/R/functions_cleane.R
MetProc/vignettes
MetProc/vignettes/using-MetProc.Rmd
MetProc/vignettes/pp_bio_corr.png
MetProc/vignettes/removed.png
MetProc/vignettes/metrics.png
MetProc/vignettes/retained.png
MetProc/MD5
MetProc/build
MetProc/build/vignette.rds
MetProc/DESCRIPTION
MetProc/man
MetProc/man/sampledata.Rd MetProc/man/MetProc-package.Rd MetProc/man/subset_met.Rd MetProc/man/heatmap_res.Rd MetProc/man/run_metric.Rd MetProc/man/met_proc.Rd MetProc/man/get_missing.Rd MetProc/man/plot_pp_sample_missing.Rd MetProc/man/write.met.Rd MetProc/man/corr_metric.Rd MetProc/man/get_group.Rd MetProc/man/plot_metric.Rd MetProc/man/read.met.Rd

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