Start the Graphical User Interface for MetSizeR. The MetSizeR GUI provides a user friendly method for sample size estimation for both targeted and NMR metabolomic experiments even when experimental pilot data is not available.
MetSizeR GUI options:
|File||Read in data and covariates, quit|
|Open||upload the txt file containing the spectrum|
|covariates||upload the txt file containing the covariates|
|demo_nmr_pilot_data||upload the demonstration NMR data already in MetSizeR|
|Quit||dispose the GUI|
|Sample size||sample size estimation|
|pilot data||sample size estimation with experimental pilot data|
|no pilot data||sample size estimation with no experimental pilot data|
|NMR data||sample size estimation for a NMR experiment|
|Targeted||sample size estimation for a targeted experiment|
|Spectral bins||number of spectral bins from the NMR experiment|
|Metabolites||number of metabolites for targeted analysis|
|Proportion of significant bins||proportion of spectral bins expected to be significant|
|Proportion of significant metabolites||proportion of metabolites expected to be significant|
|Models||different types of models available|
|ncovars||number of covariates for the PPCCA model|
|Target FDR||level of control over type I errors|
|Sample size per group||smallest sample size to be considered in each group|
|Save results in R directory||save results in the R working directory|
|calculate||estimate the sample size|
|Plot proportion of significant bins||assess the effect of varying the expected proportion of significant|
|Plot proportion of significant metabolites||assess the effect of varying the expected proportion of proportion|
|of significant metabolites|
|MetSizeR status||displays if MetSize has finished estimating the sample size|
|Help||manual for MetSizeR|
|manual||manual for MetSizeR|
MetSizeR is built upon gWidgets package. Make sure gWidgets package is properly installed.
Gift Nyamundanda [email protected], Isobel Claire Gormley, Yue Fan, William M Gallagher, Lorraine Brennan
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