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This package provides functions to perform multivariate Gaussian parameter estimation based on data with abundancedependent missingness. It implements a penalized ExpectationMaximization (EM) algorithm. The package is tailored for but not limited to proteomics data applications, in which a large proportion of the data are often missingnotatrandom with lower values (or absolute values) more likely to be missing.
Package details 


Author  Lin Chen <lchen@health.bsd.uchicago.edu> and Pei Wang <pwang@fhcrc.org> 
Date of publication  20140125 00:37:55 
Maintainer  Lin Chen <lchen@health.bsd.uchicago.edu> 
License  GPL 
Version  1.0 
Package repository  View on CRAN 
Installation 
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