Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.
Package details |
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Author | Rachel Marceau West, Shannon T. Holloway |
Maintainer | Shannon T. Holloway <shannon.t.holloway@gmail.com> |
License | GPL-2 |
Version | 1.3 |
Package repository | View on CRAN |
Installation |
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