satterChiPool: Pool p-values using the Satterthwaite approximation

In PoolBal: Balancing Central and Marginal Rejection of Pooled p-Values

Pool p-values using the Satterthwaite approximation

Description

Compute the pooled p-value of dependent p-values based on the dependence present when they are all converted to chi-squared random variables by the same chi-squared quantile function.

Usage

satterChiPool(ps, covmat, kappa)

Arguments

ps	numeric vector of M p-values
covmat	M by M covariance matrix of chi-squared random variables arising from quantile transformations of ps
kappa	numeric degrees of freedom

Details

Care must be taken in the arguments for this function, as the covmat argument accepts the covariance of the transformed variables rather than the covariance of the p-values, and so passes the argument covmat directly to the function that computes the Satterthwaite approximation. For the case of genetic markers, the 'convertGeneticSigma' function provides the appropriate matrix given a genetic correlation matrix.

Value

A pooled p-value between 0 and 1.

Author(s)

Chris Salahub

PoolBal documentation built on Nov. 22, 2023, 5:07 p.m.