RRate: Estimating Replication Rate for Genome-Wide Association Studies

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Replication Rate (RR) is the probability of replicating a statistically significant association in genome-wide association studies. This R-package provide the estimation method for replication rate which makes use of the summary statistics from the primary study. We can use the estimated RR to determine the sample size of the replication study, and to check the consistency between the results of the primary study and those of the replication study.

Author
Wei Jiang, Jing-Hao Xue and Weichuan Yu
Date of publication
2016-08-17 10:40:27
Maintainer
Wei Jiang <wjiangaa@connect.ust.hk>
License
GPL-3
Version
1.0

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Man pages

HLtest
Hosmer-Lemeshow test
repSampleSizeRR
Sample size determination for the replication study based on...
RRate-functions
Estimating Replication Rate for primary associations
RRate-package
\Sexpr[results=rd,stage=build]{tools:::Rd_package_title("RRate")}
SEest
Estimating standard error of the observed log-odds ratio
smryStats
Example summary statistics

Files in this package

RRate
RRate/NAMESPACE
RRate/data
RRate/data/param.rda
RRate/data/smryStats1.rda
RRate/data/smryStats2.rda
RRate/R
RRate/R/HLtest.R
RRate/R/RRate.R
RRate/MD5
RRate/build
RRate/build/partial.rdb
RRate/DESCRIPTION
RRate/man
RRate/man/RRate-package.Rd
RRate/man/smryStats.Rd
RRate/man/SEest.Rd
RRate/man/RRate-functions.Rd
RRate/man/repSampleSizeRR.Rd
RRate/man/HLtest.Rd