SCORE2_Diabetes: SCORE2-Diabetes

In RiskScorescvd: Cardiovascular Risk Scores Calculator

SCORE2-Diabetes

Description

This function calculates the 10-year cardiovascular risk estimation for patients aged 40 to 69 years with type 2 diabetes without atherosclerotic cardiovascular disease (ASCVD) or severe target organ damage (TOD) using the \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")} SCORE2-Diabetes algorithm. Risk score is expressed as percentage in one decimal place. It also categorises these patients into different risk groups.

Usage

SCORE2_Diabetes(
  Risk.region,
  Age,
  Gender,
  smoker,
  systolic.bp,
  total.chol,
  total.hdl,
  diabetes,
  diabetes.age,
  HbA1c,
  eGFR,
  classify = FALSE
)

Arguments

Risk.region	Input character to indicate an European risk region group the patient belongs to. The allowed categories are Low Moderate High Very high
Age	Input positive integer to indicate the age of the patient.
Gender	Input character to indicate an European risk region group the patient belongs to. The allowed categories are male female
smoker	Input integer 0 or 1 to indicate if the patient is a current smoker. 0 stands for patient is either a former/past smoker or a non-smoker. 1 stands for patient is a current smoker.
systolic.bp	Input positive numeric value to indicate the patient's systolic blood pressure in mm HG.
total.chol	Input positive numeric value to indicate the patient's total cholesterol in mmol/L.
total.hdl	Input positive numeric value to indicate the patient's high-density lipoprotein (HDL) in mmol/L.
diabetes	Input integer 0 or 1 to indicate if the patient has diabetes. 0 stands for not having diabetes. 1 stands for having diabetes.
diabetes.age	Input positive integer to indicate the age when the patient is diagnosed with diabetes. It can be set to NA if patient is not diabetic.
HbA1c	Input positive numeric value to indicate the patient's hemoglobin A1C (HbA1c) in mmol/mol.
eGFR	Input positive numeric value to indicate the patient's estimated glomerular filtration rate (eGFR) in ml/min/1.73m^2.
classify	When set to TRUE, the function will return the patient's risk group based on the SCORE2-Diabetes risk score in percentage rounded to one decimal place. Default: FALSE. Risk groups are classified based on Figure 3 from the \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad192")} 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: SCORE2-Diabetes Score 10-year Cardiovascular Disease (CVD) Risk Group <5\% Low risk 5\% to <10\% Moderate risk 10\% to <20\% High risk \ge20\% Very high risk

Details

\Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")}

was developed by extending the SCORE2 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")} algorithms using 229460 participants (43706 CVD events) with type 2 diabetes and without previous CVD from four population data sources [Scottish Care Information—Diabetes (SCID), Clinical Practice Research Datalink (CPRD), UK Biobank (UKB), Emerging Risk Factors Collaboration (ERFC)] across seven countries (England, Wales, Scotland, France, Germany, Italy, and the USA).

Value

SCORE2-Diabetes risk \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")} score expressed as a positive percentage rounded to one decimal place when classify is FALSE. A patient's risk group when classify is TRUE.

References

Primary Paper

• SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration, SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe, Eur Heart J, 44:2544–2556, \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")}

Clinical Practice Guidelines

• Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA,vAntunes MJ, Christodorescu RM, Crawford C, Angelantonio ED, Eliasson B, Espinola-Klein C, Fauchier L, Halle M, Herrington WG, Kautzky-Willer A, Lambrinou E, Lesiak M, Lettino M, McGuire DK, Mullens W, Rocca B, Sattar N, ESC Scientific Document Group, 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: Developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC), Eur Heart J, 44:4043–4140, \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1093/eurheartj/ehad260")}

Examples

# 60 years old male from low risk region
# who is a non-smoker, diabetic at age 60
# with a systolic blood pressure of 140 mmHg,
# total cholesterol of 5.5 mmol/L,
# HDL cholesterol of 1.3 mmol/L,
# HbA1c of 50 mmol/mol and
# eGFR of 90 mL/min/1.73m2
# will have a risk score of 8.4 and
# at moderate risk of CVD.

SCORE2_Diabetes(
  Risk.region = "Low",
  Age = 60,
  Gender = "male",
  smoker = 0,
  systolic.bp = 140,
  total.chol = 5.5,
  total.hdl = 1.3,
  diabetes = 1,
  diabetes.age = 60,
  HbA1c = 50,
  eGFR = 90,
  classify = FALSE
)

SCORE2_Diabetes(
  Risk.region = "Low",
  Age = 60,
  Gender = "male",
  smoker = 0,
  systolic.bp = 140,
  total.chol = 5.5,
  total.hdl = 1.3,
  diabetes = 1,
  diabetes.age = 60,
  HbA1c = 50,
  eGFR = 90,
  classify = TRUE
)

RiskScorescvd documentation built on June 27, 2024, 5:13 p.m.