conduct.phase2: Function to identify the most promising...

In SAME: Seamless Adaptive Multi-Arm Multi-Stage Enrichment

Function to identify the most promising treatment-biomarker-linked subgroup

Description

This function is used to estimate the effect size of each subgroup and to select the most promising subgroup.

Usage

conduct.phase2(formula, surv, event, data)

Arguments

formula	a formula object, with the combinations of treatment and biomarker term, e.g., formula = "T1:B1+T1:B2+T2:B1+T2:B2"
surv	survival time
event	the status indicator, 0=alive, 1=dead
data	a data.frame in which to interpret the variables named in the formula

Value

conduct.phase2() select the most effective subgroup and returns the estimated hazard ratio.

Examples

conduct.phase2(formula = "T1:B1+T1:B2+T2:B1+T2:B2", surv = "surv",
event = "death", data = "example.1")

SAME documentation built on Jan. 16, 2023, 5:06 p.m.