Description Usage Arguments Details Value References Examples

This function performs a LASSO logistic regression model using a bootstrap ranking procedure, namely the BRLasso logistic regression model, produces an optimal set of predictors and returns the robust estimations of coefficients of the selected predictors.

1 | ```
BRLasso(x, y, B = 5, Boots = 100, kfold = 10, seed = 0123)
``` |

`x` |
predictor matrix. |

`y` |
response variable, a factor object with values of 0 and 1. |

`B` |
the number of external loop for intersection operation, with the default value 5. |

`Boots` |
the number of internal loop for bootstrap sampling, with the default value 100. |

`kfold` |
the number of folds of cross validation - default is 10. Although kfold can be as large as the sample size (leave-one-out CV), it is not recommended for large datasets. Smallest value allowable is kfold=3. |

`seed` |
the seed for random sampling, with the default value 0123. |

This function runs the LASSO logistic regression model using a bootstrap ranking procedure. The bootstrap ranking procedure generates a LASSO estimates matrix representing variable ranking according to importance, and runs the external intersection operation to extract a panel of informative variables. Like the Bolasso, the bootstrap ranking procedure performs the intersection operation to extract relevant variables from sufficiently many different data sets using the sample bootstrapping method. However, instead of directly intersecting several sets of non-zero LASSO estimates, the model generates a LASSO estimate matrix representing variable ranking according to their importance, and then intersects to obtain a robust result. During each internal loop, bootstrap samples are generated by randomly selecting n individuals with replacement from a given data set of n individuals. For each such sample, LASSO regression coefficients are estimated for all variables, and the average estimation across internal bootstraps is calculated as the measurement of variable importance. Specific values of B and Boots parameters should be supplied, however B=5 and Boots=100 is proposed by default. Users can reduce the running time by using 3-fold CV, but the proposed 10-fold CV is assumed by default.

`B` |
the number of external loop for intersection operation. |

`Boots` |
the number of internal loop for bootstrap sampling. |

`var.selected` |
significant variables that are selected by the BRLasso model. |

`var.coef` |
coefficients of the selected significant variables. |

[1] Guo, P., Zeng, F., Hu, X., Zhang, D., Zhu, S., Deng, Y., & Hao, Y. (2015). Improved Variable Selection Algorithm Using a LASSO-Type Penalty, with an Application to Assessing Hepatitis B Infection Relevant Factors in Community Residents. PLoS One, 27;10(7):e0134151.

[2] Friedman, J., Hastie, T. and Tibshirani, R. (2008). Regularization Paths for Generalized Linear Models via Coordinate Descent. Journal of Statistical Software, 33(1), 1-22.

1 2 3 4 5 6 7 8 9 10 11 12 | ```
library(datasets)
head(iris)
X <- as.matrix(subset(iris, iris$Species!="setosa")[, -5])
Y <- as.factor(ifelse(subset(iris, iris$Species!="setosa")[, 5]=='versicolor', 0, 1))
# Fit a bootstrap ranking LASSO (BRLasso) logistic regression model.
# The parameters of B and Boots in the following example are set as small values to
# reduce the running time, however the default values are proposed.
BRLasso.fit <- BRLasso(x=X, y=Y, B=2, Boots=5, seed=0123)
# Significant variables that are selected by the BRLasso model.
BRLasso.fit$var.selected
# Coefficients of the selected variables.
BRLasso.fit$var.coef
``` |

```
Loading required package: glmnet
Loading required package: Matrix
Loading required package: foreach
Loaded glmnet 2.0-12
Sepal.Length Sepal.Width Petal.Length Petal.Width Species
1 5.1 3.5 1.4 0.2 setosa
2 4.9 3.0 1.4 0.2 setosa
3 4.7 3.2 1.3 0.2 setosa
4 4.6 3.1 1.5 0.2 setosa
5 5.0 3.6 1.4 0.2 setosa
6 5.4 3.9 1.7 0.4 setosa
Step 1-Current iteration: 1
Step 1-Current iteration: 2
Step 1-Current iteration: 3
Step 1-Current iteration: 4
Step 1-Current iteration: 5
Step 2-Current iteration: 1
Step 1-Current iteration: 1
Step 1-Current iteration: 2
Step 1-Current iteration: 3
Step 1-Current iteration: 4
Step 1-Current iteration: 5
Step 2-Current iteration: 2
[1] "Petal.Width"
Petal.Width
16.96213
```

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