plot_lmmModel: Plotting of tumor growth data from a fitted model

In SynergyLMM: Statistical Framework for in Vivo Drug Combination Studies

Plotting of tumor growth data from a fitted model

Description

Vizualization of tumor growth data and linear mixed model fitted regression line for the fixed effects. This functions returns a ggplot2 plot, allowing for further personalization.

Usage

plot_lmmModel(
  model,
  trt_control = "Control",
  drug_a = "Drug_A",
  drug_b = "Drug_B",
  drug_c = NA,
  combination = "Combination"
)

Arguments

model	An object of class "lme" representing the linear mixed-effects model fitted by lmmModel().
trt_control	String indicating the name assigned to the 'Control' group.
drug_a	String indicating the name assigned to the 'Drug A' group.
drug_b	String indicating the name assigned to the 'Drug B' group.
drug_c	String indicating the name assigned to the 'Drug C' group (if present).
combination	String indicating the name assigned to the Combination ('Drug A' + 'Drug B', or 'Drug A' + 'Drug B' + 'Drug C') group.

Value

A ggplot2 plot (see ggplot2::ggplot() for more details) showing the tumor growth data represented as log(relative tumor volume) versus time since treatment initiation. The regression lines corresponding to the fixed effects for each treatment group are also plotted.

Examples

data(grwth_data)
# Fit the model
lmm <- lmmModel(
  data = grwth_data,
  sample_id = "subject",
  time = "Time",
  treatment = "Treatment",
  tumor_vol = "TumorVolume",
  trt_control = "Control",
  drug_a = "DrugA",
  drug_b = "DrugB",
  combination = "Combination",
  show_plot = FALSE
  )
# Default plot
plot_lmmModel(lmm,
trt_control = "Control",
drug_a = "DrugA",
drug_b = "DrugB",
combination = "Combination"
)
# Adding ggplot2 elements
plot_lmmModel(lmm,
trt_control = "Control",
drug_a = "DrugA",
drug_b = "DrugB",
combination = "Combination"
) + ggplot2::labs(title = "Example Plot") + ggplot2::theme(legend.position = "top")

SynergyLMM documentation built on April 4, 2025, 4:13 a.m.