TopDom: An Efficient and Deterministic Method for Identifying Topological Domains in Genomes

The 'TopDom' method identifies topological domains in genomes from Hi-C sequence data (Shin et al., 2016 <doi:10.1093/nar/gkv1505>). The authors published an implementation of their method as an R script (two different versions; also available in this package). This package originates from those original 'TopDom' R scripts and provides help pages adopted from the original 'TopDom' PDF documentation. It also provides a small number of bug fixes to the original code.

Getting started

Package details

AuthorHenrik Bengtsson [aut, cre, cph] (ORCID: <https://orcid.org/0000-0002-7579-5165>), Hanjun Shin [aut, ctr, cph], Harris Lazaris [ctr, cph] (PhD Student, NYU, ORCID: <https://orcid.org/0000-0002-7345-8288>), Gangqing Hu [ctr, cph] (Staff Scientist, NIH, ORCID: <https://orcid.org/0000-0001-5453-6888>), Xianghong Zhou [ctr]
MaintainerHenrik Bengtsson <henrikb@braju.com>
LicenseGPL
Version0.10.2
URL https://github.com/HenrikBengtsson/TopDom
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("TopDom")

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TopDom documentation built on Aug. 31, 2026, 5:06 p.m.