get_oc_gBOIN_continuous: Generate operating characteristics for finding the maximum...

In UnifiedDoseFinding: Dose-Finding Methods for Non-Binary Outcomes

Generate operating characteristics for finding the maximum tolerated dose (MTD) using gBOIN design

Description

Obtain the operating characteristics of the general Bayesian optimal interval (gBOIN) design (Mu et al. 2017) for maximum tolerated dose (MTD)-based dosing-finding trials under the continuous measure

Usage

get_oc_gBOIN_continuous(target, c_true, ncohort, cohortsize,
                        n.earlystop = 100, ntrial,
                        mu_1 = 0.6 * target,
                        mu_2 = 1.4 * target,
                        startdose = 1, seed = 100)

Arguments

target	the continuous target score
c_true	the true mean value of the continuous measure
ncohort	the number of cohorts
cohortsize	the cohort size
n.earlystop	the early stopping parameter. The default value is n.earlystop = 100
ntrial	the number of simulated trials
mu_1	the lower bound. The default value is mu_1 = 0.6 * target
mu_2	the upper bound. The default value is mu_2 = 1.4 * target
startdose	the starting dose level. The default value is startdose = 1
seed	the seed. The default value is seed = 100

Value

get_oc_gBOIN_continuous() returns the operating characteristics of generalized Bayesian optimal interval design (gBOIN) as a list object, including: (1) selection percentage of each dose, (2) the average number of patients treated at each dose

Author(s)

Chia-Wei Hsu, Haitao Pan, Rongji Mu

References

Mu, Rongji, Ying Yuan, Jin Xu, Sumithra J. Mandrekar, and Jun Yin. "gBOIN: a unified model-assisted phase I trial design accounting for toxicity grades, and binary or continuous end points." Journal of the Royal Statistical Society. Series C: Applied Statistics 68, no. 2 (2019): 289-308.

Examples

target <- 1.47
c_true <- c(0.11, 0.25, 0.94, 1.47, 2.38, 2.40)
ncohort <- 10
cohortsize <- 3
ntrial <- 4000
get_oc_gBOIN_continuous(target = target, c_true = c_true,
                        ncohort = ncohort, cohortsize = cohortsize,
                        ntrial = ntrial)

UnifiedDoseFinding documentation built on Oct. 16, 2022, 1:10 a.m.