bimixt: Estimates Mixture Models for Case-Control Data

Share:

Estimates non-Gaussian mixture models of case-control data. The four types of models supported are binormal, two component constrained, two component unconstrained, and four component. The most general model is the four component model, under which both cases and controls are distributed according to a mixture of two unimodal distributions. In the four component model, the two component distributions of the control mixture may be distinct from the two components of the case mixture distribution. In the two component unconstrained model, the components of the control and case mixtures are the same; however the mixture probabilities may differ for cases and controls. In the two component constrained model, all controls are distributed according to one of the two components while cases follow a mixture distribution of the two components. In the binormal model, cases and controls are distributed according to distinct unimodal distributions. These models assume that Box-Cox transformed case and control data with a common lambda parameter are distributed according to Gaussian mixture distributions. Model parameters are estimated using the expectation-maximization (EM) algorithm. Likelihood ratio test comparison of nested models can be performed using the lr.test function. AUC and PAUC values can be computed for the model-based and empirical ROC curves using the auc and pauc functions, respectively. The model-based and empirical ROC curves can be graphed using the roc.plot function. Finally, the model-based density estimates can be visualized by plotting a model object created with the bimixt.model function.

Author
Michelle Winerip, Garrick Wallstrom, Joshua LaBaer
Date of publication
2015-08-25 00:54:26
Maintainer
Michelle Winerip <mwinerip@asu.edu>
License
GPL (>= 3)
Version
1.0

View on CRAN

Man pages

bc.binorm
bc.binorm
bc.fourcomp
bc.fourcomp
bc.twocomp
bc.twocomp
bimixt.model
bimixt.model
bimixt-package
bimixt
boxcox
boxcox
boxcox.deriv
boxcox.deriv
boxcox.inv
boxcox.inv
boxcox.inv.density
boxcox.inv.density
em.twocomp.m1
em.twocomp.m1
em.twocomp.m2
em.twocomp.m2
em.twocomp.m3
em.twocomp.m3
lambda
lambda
lr.test
lr.test
maxll
maxll
mn
mn
plot.model
plot.model
print.model
print.model
prop
prop
rmix
rmix
ROCauc
ROCauc
ROCcoords
ROCcoords
ROCpauc
ROCpauc
ROCplot
ROCplot
stdev
stdev
summary.model
summary.model
type
type

Files in this package

bimixt
bimixt/NAMESPACE
bimixt/R
bimixt/R/r23.R
bimixt/MD5
bimixt/DESCRIPTION
bimixt/man
bimixt/man/plot.model.Rd
bimixt/man/ROCplot.Rd
bimixt/man/type.Rd
bimixt/man/prop.Rd
bimixt/man/ROCcoords.Rd
bimixt/man/ROCpauc.Rd
bimixt/man/boxcox.deriv.Rd
bimixt/man/stdev.Rd
bimixt/man/boxcox.inv.density.Rd
bimixt/man/lr.test.Rd
bimixt/man/bc.fourcomp.Rd
bimixt/man/bc.twocomp.Rd
bimixt/man/bimixt.model.Rd
bimixt/man/lambda.Rd
bimixt/man/em.twocomp.m3.Rd
bimixt/man/rmix.Rd
bimixt/man/boxcox.Rd
bimixt/man/mn.Rd
bimixt/man/bimixt-package.Rd
bimixt/man/maxll.Rd
bimixt/man/em.twocomp.m2.Rd
bimixt/man/summary.model.Rd
bimixt/man/ROCauc.Rd
bimixt/man/boxcox.inv.Rd
bimixt/man/bc.binorm.Rd
bimixt/man/em.twocomp.m1.Rd
bimixt/man/print.model.Rd