parkinson: parkinson Bayesian Network

parkinsonR Documentation

parkinson Bayesian Network

Description

AI reveals insights into link between CD33 and cognitive impairment in Alzheimer's disease.

Format

A Gaussian Bayesian network to simulate a down-expression of the putative drug target CD33, including potential impact on cognitive impairment and brain pathophysiology. Probabilities were given within the referenced paper. The vertices are:

Cluster_1
Cluster_2
Cluster_3
Cluster_4
Cluster_6
Cluster_7
Cluster_8
Cluster_9
Cluster_11
Cluster_14
Cluster_15
Cluster_16
Cluster_17
Cluster_18
Cluster_19
Cluster_20
Cluster_21
Cluster_25
Cluster_26
Cluster_27
cognition
PatDemo_educ
PatDemo_sex
PatDemo_apoe
PatDemo_age
PatDemo_brainregion
REL
PPARG
TRAF1
GRIN1
CASP7
NAV3
DLG4
CD33

Value

An object of class bn.fit. Refer to the documentation of bnlearn for details.

References

Raschka, T., Sood, M., Schultz, B., Altay, A., Ebeling, C., & Frohlich, H. (2023). AI reveals insights into link between CD33 and cognitive impairment in Alzheimer's Disease. PLOS Computational Biology, 19(2), e1009894.


bnRep documentation built on April 12, 2025, 1:13 a.m.