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tests/testthat/_snaps/rspt01.md
In chevron: Standard TLGs for Clinical Trials Reporting
rspt01 works as expected
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for stratified and unstratified analysis
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for unstratified analysis only
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for stratified analysis only
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works if change reference group
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) 6.7 13.3
95% CI (Wald, with correction) (-34.4, 47.7) (-26.7, 53.4)
p-value (Fisher's Exact Test) 1.0000 0.6999
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) 6.7 13.3
95% CI (Wald, with correction) (-34.4, 47.7) (-26.7, 53.4)
p-value (Fisher's Exact Test) 1.0000 0.6999
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Stratified Analysis
Difference in Response rate (%) 7.7 16.7
95% CI (CMH, without correction) (-26.2, 41.6) (-14.0, 47.4)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.3760
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works if change statistic methods
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, without correction) (42.8, 90.5) (35.2, 84.8) (51.0, 95.7)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, without correction) (-41.1, 27.7) (-26.0, 39.4)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, without correction) (4.29, 49.05) (4.29, 49.05) (21.42, 71.91)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, without correction) (15.21, 64.79) (9.48, 57.19) (4.29, 49.05)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, without correction) (9.48, 57.19) (15.21, 64.79) (4.29, 49.05)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo
(N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%)
95% CI (Wald, without correction) (42.8, 90.5) (35.2, 84.8)
Unstratified Analysis
Difference in Response rate (%) -6.7
95% CI (Wald, without correction) (-41.1, 27.7)
p-value (Fisher's Exact Test) 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33)
Stratified Analysis
Difference in Response rate (%) -6.7
95% CI (Anderson-Hauck) (-45.6, 32.3)
p-value (Chi-Squared Test with Schouten Correction) 0.8522
Odds Ratio (95% CI) 0.75 (0.17 - 3.33)
Complete Response (CR) 4 (26.7%) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05) (4.29, 49.05)
Partial Response (PR) 6 (40.0%) 5 (33.3%)
95% CI (Wald, without correction) (15.21, 64.79) (9.48, 57.19)
Stable Disease (SD) 5 (33.3%) 6 (40.0%)
95% CI (Wald, without correction) (9.48, 57.19) (15.21, 64.79)
\s\n C: Combination
(N=15)
——————————————————————————————————————————————————————————————————————————
Responders 11 (73.3%)
95% CI (Wald, without correction) (51.0, 95.7)
Unstratified Analysis
Difference in Response rate (%) 6.7
95% CI (Wald, without correction) (-26.0, 39.4)
p-value (Fisher's Exact Test) 1.0000
Odds Ratio (95% CI) 1.37 (0.29 - 6.60)
Stratified Analysis
Difference in Response rate (%) 6.7
95% CI (Anderson-Hauck) (-30.5, 43.9)
p-value (Chi-Squared Test with Schouten Correction) 0.8447
Odds Ratio (95% CI) 1.37 (0.29 - 6.60)
Complete Response (CR) 7 (46.7%)
95% CI (Wald, without correction) (21.42, 71.91)
Partial Response (PR) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05)
Stable Disease (SD) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05)
rspt01 works if change confidence interval
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
90% CI (Wald, with correction) (43.3, 90.0) (35.9, 84.1) (51.2, 95.4)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
90% CI (Wald, with correction) (-42.2, 28.9) (-27.5, 40.8)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
90% CI (Wald, with correction) (4.55, 48.78) (4.55, 48.78) (22.15, 71.19)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
90% CI (Wald, with correction) (15.86, 64.14) (9.98, 56.69) (4.55, 48.78)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
90% CI (Wald, with correction) (9.98, 56.69) (15.86, 64.14) (4.55, 48.78)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
90% CI (Wald, with correction) (43.3, 90.0) (35.9, 84.1) (51.2, 95.4)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
90% CI (Wald, with correction) (-42.2, 28.9) (-27.5, 40.8)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
90% CI (CMH, without correction) (-36.1, 20.8) (-14.5, 32.9)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
90% CI (Wald, with correction) (4.55, 48.78) (4.55, 48.78) (22.15, 71.19)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
90% CI (Wald, with correction) (15.86, 64.14) (9.98, 56.69) (4.55, 48.78)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
90% CI (Wald, with correction) (9.98, 56.69) (15.86, 64.14) (4.55, 48.78)
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rspt01 works as expected
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for stratified and unstratified analysis
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for unstratified analysis only
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, with correction) (-47.7, 34.4) (-32.7, 46.0)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works as expected for stratified analysis only
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
95% CI (CMH, without correction) (-41.6, 26.2) (-19.0, 37.5)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works if change reference group
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) 6.7 13.3
95% CI (Wald, with correction) (-34.4, 47.7) (-26.7, 53.4)
p-value (Fisher's Exact Test) 1.0000 0.6999
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, with correction) (39.5, 93.9) (31.9, 88.1) (47.6, 99.0)
Unstratified Analysis
Difference in Response rate (%) 6.7 13.3
95% CI (Wald, with correction) (-34.4, 47.7) (-26.7, 53.4)
p-value (Fisher's Exact Test) 1.0000 0.6999
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Stratified Analysis
Difference in Response rate (%) 7.7 16.7
95% CI (CMH, without correction) (-26.2, 41.6) (-14.0, 47.4)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.3760
Odds Ratio (95% CI) 1.33 (0.30 - 5.91) 1.83 (0.39 - 8.57)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, with correction) (0.95, 52.38) (0.95, 52.38) (18.09, 75.25)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, with correction) (11.87, 68.13) (6.14, 60.52) (0.95, 52.38)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, with correction) (6.14, 60.52) (11.87, 68.13) (0.95, 52.38)
rspt01 works if change statistic methods
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
95% CI (Wald, without correction) (42.8, 90.5) (35.2, 84.8) (51.0, 95.7)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
95% CI (Wald, without correction) (-41.1, 27.7) (-26.0, 39.4)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
95% CI (Wald, without correction) (4.29, 49.05) (4.29, 49.05) (21.42, 71.91)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
95% CI (Wald, without correction) (15.21, 64.79) (9.48, 57.19) (4.29, 49.05)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
95% CI (Wald, without correction) (9.48, 57.19) (15.21, 64.79) (4.29, 49.05)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo
(N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%)
95% CI (Wald, without correction) (42.8, 90.5) (35.2, 84.8)
Unstratified Analysis
Difference in Response rate (%) -6.7
95% CI (Wald, without correction) (-41.1, 27.7)
p-value (Fisher's Exact Test) 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33)
Stratified Analysis
Difference in Response rate (%) -6.7
95% CI (Anderson-Hauck) (-45.6, 32.3)
p-value (Chi-Squared Test with Schouten Correction) 0.8522
Odds Ratio (95% CI) 0.75 (0.17 - 3.33)
Complete Response (CR) 4 (26.7%) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05) (4.29, 49.05)
Partial Response (PR) 6 (40.0%) 5 (33.3%)
95% CI (Wald, without correction) (15.21, 64.79) (9.48, 57.19)
Stable Disease (SD) 5 (33.3%) 6 (40.0%)
95% CI (Wald, without correction) (9.48, 57.19) (15.21, 64.79)
\s\n C: Combination
(N=15)
——————————————————————————————————————————————————————————————————————————
Responders 11 (73.3%)
95% CI (Wald, without correction) (51.0, 95.7)
Unstratified Analysis
Difference in Response rate (%) 6.7
95% CI (Wald, without correction) (-26.0, 39.4)
p-value (Fisher's Exact Test) 1.0000
Odds Ratio (95% CI) 1.37 (0.29 - 6.60)
Stratified Analysis
Difference in Response rate (%) 6.7
95% CI (Anderson-Hauck) (-30.5, 43.9)
p-value (Chi-Squared Test with Schouten Correction) 0.8447
Odds Ratio (95% CI) 1.37 (0.29 - 6.60)
Complete Response (CR) 7 (46.7%)
95% CI (Wald, without correction) (21.42, 71.91)
Partial Response (PR) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05)
Stable Disease (SD) 4 (26.7%)
95% CI (Wald, without correction) (4.29, 49.05)
rspt01 works if change confidence interval
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
—————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
90% CI (Wald, with correction) (43.3, 90.0) (35.9, 84.1) (51.2, 95.4)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
90% CI (Wald, with correction) (-42.2, 28.9) (-27.5, 40.8)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
90% CI (Wald, with correction) (4.55, 48.78) (4.55, 48.78) (22.15, 71.19)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
90% CI (Wald, with correction) (15.86, 64.14) (9.98, 56.69) (4.55, 48.78)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
90% CI (Wald, with correction) (9.98, 56.69) (15.86, 64.14) (4.55, 48.78)
Code
cat(export_as_txt(res, lpp = 100))
Output
A: Drug X B: Placebo C: Combination
(N=15) (N=15) (N=15)
———————————————————————————————————————————————————————————————————————————————————————————————————
Responders 10 (66.7%) 9 (60.0%) 11 (73.3%)
90% CI (Wald, with correction) (43.3, 90.0) (35.9, 84.1) (51.2, 95.4)
Unstratified Analysis
Difference in Response rate (%) -6.7 6.7
90% CI (Wald, with correction) (-42.2, 28.9) (-27.5, 40.8)
p-value (Fisher's Exact Test) 1.0000 1.0000
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Stratified Analysis
Difference in Response rate (%) -7.7 9.2
90% CI (CMH, without correction) (-36.1, 20.8) (-14.5, 32.9)
p-value (Cochran-Mantel-Haenszel Test) 0.6699 0.6257
Odds Ratio (95% CI) 0.75 (0.17 - 3.33) 1.37 (0.29 - 6.60)
Complete Response (CR) 4 (26.7%) 4 (26.7%) 7 (46.7%)
90% CI (Wald, with correction) (4.55, 48.78) (4.55, 48.78) (22.15, 71.19)
Partial Response (PR) 6 (40.0%) 5 (33.3%) 4 (26.7%)
90% CI (Wald, with correction) (15.86, 64.14) (9.98, 56.69) (4.55, 48.78)
Stable Disease (SD) 5 (33.3%) 6 (40.0%) 4 (26.7%)
90% CI (Wald, with correction) (9.98, 56.69) (15.86, 64.14) (4.55, 48.78)
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