amd: CARMS scores

In clusrank: Wilcoxon Rank Tests for Clustered Data

CARMS scores

Description

A data set from a research on complement factor H R1210C rare variant and its associated phenotype. This data set contains Clinical Age-Related Maculopathy Staging (CARMS) scores from a total of 143 patients (283 eyes), including 62 patients with the rare variant, The data is from the lab of Dr. Johanna M. Seddon,

Format

A data frame with 283 rows and 7 variables.

• ID patient identifier

• Eye OD (right eye), OS(left eye)

• Variant 1: No R1210C Variant; 2: R1210C Variant

• CARMS Patient's last CARMS grade, related to age-related macular degeneration (AMD). 1: no AMD; 2: early AMD; 3: intermediate AMD; 4: geographic atroph(advanced dry); 5: neovascular disease (advanced wet)

• Age_group 1: < 70 years; 2: 70 to 79.9 years; 3: >= 80 years

• Sex 1: male; 2: female

• AgeSex 1: agegroup = 1, sex = 1; 2: agegroup = 2, sex = 1; 3: agegroup = 3, sex = 1; 4: agegroup = 1, sex = 2; 5: agegroup = 2, sex = 2; 6: agegroup = 3, sex = 2;

Note

CARMS grades were assessed separately for the two advanced stages (4 and 5): 1. CARMS 1,2,3, and 4 was assessed; 2. CARMS 1,2,3, and 5 was assessed

Source

The data came from Seddon's lab.

References

Seddon JM, Sharma S, Adelman RA (2006) Evaluation of the Clinical Age-related Maculopathy Staging System. Ophthalmology, 113, 260-266.

Ferrara D, Seddon JM (2015) Phenotypic characterization of complement factor H R1210C rare genetic variant in age-related macular degeneration JAMA Ophthalmol, 2015 Apr 16. doi:10.1001/jamaophthalmol.2015.0814.

Examples

data(amd)
clusWilcox.test(CARMS ~ Variant + cluster(ID), data = amd,
               subset = CARMS %in% c(1, 2, 3, 4), method = "rgl", alternative = "two")
clusWilcox.test(CARMS ~ Variant + cluster(ID), data = amd,
               subset = CARMS %in% c(1, 2, 3, 4), method = "ds", alternative = "two")
clusWilcox.test(CARMS ~ Variant + cluster(ID) + stratum(AgeSex), data = amd,
               subset = CARMS %in% c(1, 2, 3, 4), alternative = "two")

clusrank documentation built on Aug. 12, 2022, 9:06 a.m.