We present 'corto' (Correlation Tool), a simple package to infer gene regulatory networks and visualize master regulators from gene expression data using DPI (Data Processing Inequality) and bootstrapping to recover edges. An initial step is performed to calculate all significant edges between a list of source nodes (centroids) and target genes. Then all triplets containing two centroids and one target are tested in a DPI step which removes edges. A bootstrapping process then calculates the robustness of the network, eventually readding edges previously removed by DPI. The algorithm has been optimized to run outside a computing cluster, using a fast correlation implementation. The package finally provides functions to calculate network enrichment analysis from RNASeq and ATACSeq signatures as described in the article by Giorgi lab (2020) <doi:10.1093/bioinformatics/btaa223>.
Package details 


Author  Federico M. Giorgi [aut, cre], Daniele Mercatelli [ctb], Gonzalo LopezGarcia [ctb] 
Maintainer  Federico M. Giorgi <federico.giorgi@gmail.com> 
License  LGPL3 
Version  1.1.8 
Package repository  View on CRAN 
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