denovolyzeR: Statistical Analyses of De Novo Genetic Variants

An integrated toolset for the analysis of de novo (sporadic) genetic sequence variants. denovolyzeR implements a mutational model that estimates the probability of a de novo genetic variant arising in each human gene, from which one can infer the expected number of de novo variants in a given population size. Observed variant frequencies can then be compared against expectation in a Poisson framework. denovolyzeR provides a suite of functions to implement these analyses for the interpretation of de novo variation in human disease.

AuthorJames Ware [aut, cre], Jason Homsy [ctb], Kaitlin Samocha [ctb]
Date of publication2016-08-01 14:55:41
MaintainerJames Ware <j.ware@imperial.ac.uk>
LicenseGPL-3
Version0.2.0
http://denovolyzeR.org

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Files in this package

denovolyzeR
denovolyzeR/inst
denovolyzeR/inst/CITATION
denovolyzeR/inst/doc
denovolyzeR/inst/doc/denovolyzeR_intro.Rmd
denovolyzeR/inst/doc/denovolyzeR_intro.R
denovolyzeR/inst/doc/denovolyzeR_intro.html
denovolyzeR/NAMESPACE
denovolyzeR/NEWS.md
denovolyzeR/data
denovolyzeR/data/autismDeNovos.rda
denovolyzeR/data/FMRPgenes.rda
denovolyzeR/R
denovolyzeR/R/viewProbabilityTable.R denovolyzeR/R/PermuteMultiHits.R denovolyzeR/R/denovolyzeMultiHits.R
denovolyzeR/R/sysdata.rda
denovolyzeR/R/denovolyzeR.doc.R denovolyzeR/R/FMRPgenes.doc.R denovolyzeR/R/autismDeNovos.doc.R denovolyzeR/R/parseInput.R denovolyzeR/R/denovolyze.R
denovolyzeR/vignettes
denovolyzeR/vignettes/denovolyzeR_intro.Rmd
denovolyzeR/MD5
denovolyzeR/build
denovolyzeR/build/vignette.rds
denovolyzeR/DESCRIPTION
denovolyzeR/man
denovolyzeR/man/parseInput.Rd denovolyzeR/man/autismDeNovos.Rd denovolyzeR/man/denovolyzeR.Rd denovolyzeR/man/denovolyzeMultiHits.Rd denovolyzeR/man/fmrpGenes.Rd denovolyzeR/man/PermuteMultiHits.Rd denovolyzeR/man/viewProbabilityTable.Rd denovolyzeR/man/denovolyze.Rd

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

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