drsmooth: Dose-Response Modeling with Smoothing Splines

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Provides tools for assessing the shape of a dose-response curve by testing linearity and non-linearity at user-defined cut-offs. It also provides two methods of estimating a threshold dose, or the dose at which the dose-response function transitions to significantly increasing: bi-linear (based on pkg 'segmented') and smoothed with splines (based on pkg 'mgcv').

Author
Greg Hixon [aut], Chad Thompson [aut], Anne Bichteler [aut, cre], Liz Abraham [ctb]
Date of publication
2015-09-25 00:01:50
Maintainer
Anne Bichteler <abichteler@toxstrategies.com>
License
GPL (>= 3)
Version
1.9.0

View on CRAN

Man pages

bartlett
Bartlett's
chisquare
Chi-square
dichot_smooth
Dose-response Modeling with Smoothing Splines
DIdata
Example and Test Data for drsmooth - dichotomous
dosefactor
dosefactor
DRdata
Example and Test Data for drsmooth
drsmooth
Dose-response Modeling with Smoothing Splines
drsmooth-package
drsmooth-package: Dose-response Modeling with Smoothing...
drsmooth.print
Print Formatted Matrices for drsmooth
dunnetts
Dunnett's
dunnetts.format
Format Dunnett's Test Output
dunnettst3
Dunnett's T3 Test
dunns
Dunn's Test
dunns.format
Format Dunn's Test Output
expand
Expand Summarized Dichotomous Data for drsmooth
firstDeriv
First Derivative Function(s)
fishers.exact
Fisher's Exact Test
jonckheere
Jonckheere
lbcd
Linearity Below Cut-off Dose
nlaad
Non-linearity Across All Doses
nlbcd
Non-linearity Below Cut-off Dose
noel
No/Lowest Observed Effect Levels
outlier
Outlier
pkg_prep
PkgName Prep Functions
prelimstats
Preliminary Statistics
segment
Segmented Hockey Stick Test
segment.plot
Plot Segmented Test
segment.print
Print Segmented Statistics
shapiro
Shapiro
smooth
Dose-response Modeling with Smoothing Splines
spline.plot
Plot Spline

Files in this package

drsmooth
drsmooth/inst
drsmooth/inst/CITATION
drsmooth/inst/tests
drsmooth/inst/tests/test-prelimstats.r
drsmooth/inst/tests/test-noel.r
drsmooth/inst/tests/test-spline.r
drsmooth/inst/tests/test-nlaad.r
drsmooth/tests
drsmooth/tests/test-all.R
drsmooth/NAMESPACE
drsmooth/NEWS
drsmooth/data
drsmooth/data/DRdata.rda
drsmooth/data/DIdata.rda
drsmooth/R
drsmooth/R/lbcd.r
drsmooth/R/dichot_smooth.R
drsmooth/R/prelimstats.r
drsmooth/R/drsmooth.print.r
drsmooth/R/fishers.exact.R
drsmooth/R/dunns.R
drsmooth/R/segment.plot.r
drsmooth/R/noel.r
drsmooth/R/DRdata.R
drsmooth/R/drsmooth.R
drsmooth/R/pkg_prep.r
drsmooth/R/bartlett.r
drsmooth/R/chisquare.r
drsmooth/R/jonckheere.r
drsmooth/R/drsmooth-package.R
drsmooth/R/segment.print.r
drsmooth/R/smooth.R
drsmooth/R/nlbcd.r
drsmooth/R/segment.r
drsmooth/R/nlaad.r
drsmooth/R/dunnetts.format.r
drsmooth/R/dunnettst3.r
drsmooth/R/DIdata.R
drsmooth/R/firstDeriv.R
drsmooth/R/dosefactor.r
drsmooth/R/outlier.r
drsmooth/R/dunnetts.R
drsmooth/R/dunns.format.r
drsmooth/R/expand.R
drsmooth/R/spline.plot.r
drsmooth/R/shapiro.r
drsmooth/MD5
drsmooth/DESCRIPTION
drsmooth/man
drsmooth/man/segment.print.Rd
drsmooth/man/segment.Rd
drsmooth/man/jonckheere.Rd
drsmooth/man/dunnetts.Rd
drsmooth/man/segment.plot.Rd
drsmooth/man/drsmooth.print.Rd
drsmooth/man/dunns.Rd
drsmooth/man/drsmooth-package.Rd
drsmooth/man/nlaad.Rd
drsmooth/man/spline.plot.Rd
drsmooth/man/firstDeriv.Rd
drsmooth/man/dunnettst3.Rd
drsmooth/man/pkg_prep.Rd
drsmooth/man/DRdata.Rd
drsmooth/man/fishers.exact.Rd
drsmooth/man/dosefactor.Rd
drsmooth/man/nlbcd.Rd
drsmooth/man/bartlett.Rd
drsmooth/man/DIdata.Rd
drsmooth/man/noel.Rd
drsmooth/man/lbcd.Rd
drsmooth/man/dunns.format.Rd
drsmooth/man/outlier.Rd
drsmooth/man/chisquare.Rd
drsmooth/man/dichot_smooth.Rd
drsmooth/man/shapiro.Rd
drsmooth/man/expand.Rd
drsmooth/man/dunnetts.format.Rd
drsmooth/man/drsmooth.Rd
drsmooth/man/prelimstats.Rd
drsmooth/man/smooth.Rd