helper_minimax: Helper function for minimax method.

In dtComb: Statistical Combination of Diagnostic Tests

Helper function for minimax method.

Description

The helper_minimax function calculates the combination coefficient and optimized value of given biomarkers for the minimax method.

Usage

helper_minimax(t, neg.set, pos.set, markers, status)

Arguments

t	a numeric parameter that will be estimated in minimax method for the combination score
neg.set	a numeric data frame that contains the observation with negative status
pos.set	a numeric data frame that contains the observation with positive status
markers	a numeric data frame that contains the biomarkers
status	a factor data frame that includes the actual disease status of the patients

Value

A numeric Optimized value calculated with combination scores using t

Author(s)

Serra Ilayda Yerlitas, Serra Bersan Gengec, Necla Kochan, Gozde Erturk Zararsiz, Selcuk Korkmaz, Gokmen Zararsiz

Examples

# call data
data(exampleData1)

# define the function parameters
markers <- cbind(exampleData1$ddimer, exampleData1$log_leukocyte)
status <- factor(exampleData1$group, levels = c("not_needed", "needed"))

neg.set <- markers[status == levels(status)[1], ]
pos.set <- markers[status == levels(status)[2], ]

t <- 0.5

stat <- helper_minimax(t,
  neg.set = neg.set, pos.set = pos.set,
  markers = markers, status
)

dtComb documentation built on June 24, 2024, 5:15 p.m.