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In eCerto: Statistical Tests for the Production of Reference Materials
Stability accelerated studies (Arrhenius)
The Arrhenius approach is one way to estimate the stability of a reference material
from the perspective of storage time or shelf life. As implemented in eCerto,
the estimation is based on time series data of analytes at different temperature levels $T_i$.
$T_{min}$ is used as a reference point. For each $T_i$ a linear model is calculated,
yielding potentially a slope $k_{\mathit{eff}}(T)$ indicative of analyte degradation.
Combining all $k_{\mathit{eff}}$ allows to estimate the dependency of analyte stability
on temperature and, consequently, the expected storage time at a given $T$.
The calculations are performed according to the recommendations for accelerated stability
studies in ISO GUIDE 35:2017.
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eCerto documentation built on April 12, 2025, 9:13 a.m.
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Stability accelerated studies (Arrhenius)
The Arrhenius approach is one way to estimate the stability of a reference material from the perspective of storage time or shelf life. As implemented in eCerto, the estimation is based on time series data of analytes at different temperature levels $T_i$.
$T_{min}$ is used as a reference point. For each $T_i$ a linear model is calculated, yielding potentially a slope $k_{\mathit{eff}}(T)$ indicative of analyte degradation. Combining all $k_{\mathit{eff}}$ allows to estimate the dependency of analyte stability on temperature and, consequently, the expected storage time at a given $T$.
The calculations are performed according to the recommendations for accelerated stability studies in ISO GUIDE 35:2017.
Try the eCerto package in your browser
Any scripts or data that you put into this service are public.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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