Description Usage Arguments Value Examples
Function for calculating the minimum required number of responders in the experimental group to make a GO decision in Settings 1 and 2.
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N_e |
Sample Size in the experimental group. |
delta |
Required superiority to make a "GO" decision. Corresponds to δ. |
confidence |
Required confidence to make "GO" decision. Corresponds to γ. |
e_a |
Alpha parameter of Beta Prior Distribution for the experimental response rate. Corresponds to α e. Default is 1/2. |
e_b |
Beta parameter of Beta Prior Distribution for the experimental response rate. Corresponds to β e. Default is 1/2. |
h_a |
Alpha parameter of Beta Prior Distribution for the historical control response rate. Corresponds to α h. Only needs to be specified, if RR_h and N_h are also specified. Default is 1/2. |
h_b |
Beta parameter of Beta Prior Distribution for the historical control response rate. Corresponds to β h. Only needs to be specified, if RR_h and N_h are also specified. Default is 1/2. |
RR_h |
Historical control response rate. Corresponds to p h. If specified together with N_h, function will use setting 2 from pdf. |
N_h |
Historical control sample size. Corresponds to n h. If specified together with RR_h, function will use setting 2 from pdf. |
hist_RR_c |
Point estimate of historical control repsonse rate. Corresponds to p h hat. If specified, while RR_h and N_h are not specified, function will use setting 1 from pdf. |
adapt |
Level of adapting of experimental control rate to account for patient selection bias from phase II to phase III. Corresponds to ξ. Default is 1, so no adapting. |
Integer.
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