Defines functions elaborator_perform_ttest

Documented in elaborator_perform_ttest

#' Performs t-test for changes of a laboratory parameter between two visits
#' @description
#' This function is mostly useful for generating the quantitative trend analysis plots. It returns the output of a t-test result used for colorizing the background of the plots.
#'@param data data set
#'@param treatment name of treatment group
#'@param lab_parameter name of laboratory parameter
#'@param Visit1 name of visit time point one
#'@param Visit2 name of visit time point two
#'@param lab_column column name of data which includes the laboratory parameter names
#'@return A list of class "htest" with the results of the t-test.
#'@keywords internal

elaborator_perform_ttest <- function(data, treatment, lab_parameter, Visit1 = "Randomization", Visit2 = "End of Treatment", lab_column){

  datasub <- data[data$TRTP == treatment & data[,lab_column] == lab_parameter,]

  differ <- unlist(sapply(unique(datasub$SUBJIDN), function(z){
    res <- datasub$LBORRES[datasub$SUBJIDN == z & datasub$AVISIT == Visit1] -
      datasub$LBORRES[datasub$SUBJIDN == z & datasub$AVISIT == Visit2]
    if (length(res) == 0 || is.na(res)) return(NA) else return(res)
  testres <- stats::t.test(x = differ)

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elaborator documentation built on Feb. 23, 2021, 1:06 a.m.