epoc: Endogenous Perturbation Analysis of Cancer

Estimates sparse matrices A or G using fast lasso regression from mRNA transcript levels Y and CNA profiles U. Two models are provided, EPoC A where AY + U + R = 0 and EPoC G where Y = GU + E, the matrices R and E are so far treated as noise. For details see the manual page of 'lassoshooting' and the article Rebecka Jörnsten, Tobias Abenius, Teresia Kling, Linnéa Schmidt, Erik Johansson, Torbjörn E M Nordling, Bodil Nordlander, Chris Sander, Peter Gennemark, Keiko Funa, Björn Nilsson, Linda Lindahl, Sven Nelander (2011) <doi:10.1038/msb.2011.17>.

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Package details

AuthorRebecka Jornsten, Tobias Abenius, Sven Nelander
MaintainerTobias Abenius <[email protected]>
Package repositoryView on CRAN
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epoc documentation built on Nov. 30, 2018, 4:18 p.m.