estimation_ub: Unblinded estimation of the correlation

In eselect: Adaptive Clinical Trial Designs with Endpoint Selection and Sample Size Reassessment

Unblinded estimation of the correlation

Description

This function estimates the correlation between two binary endpoints based on unblinded data.

Usage

estimation_ub(samplesize, p0_e1, p1_e1, OR1, p0_e2, p1_e2, OR2, p0_ce, p1_ce)

Arguments

samplesize	numeric parameter, sample size per arm
p0_e1	numeric parameter, probability of occurrence E1 in the control group
p1_e1	numeric parameter, probability of occurrence E1 in the treatment group
OR1	numeric parameter, Odds ratio for the endpoint 1 (design)
p0_e2	numeric parameter, probability of occurrence E2 in the control group
p1_e2	numeric parameter, probability of occurrence E2 in the treatment group
OR2	numeric parameter, Odds ratio for the endpoint 2 (design)
p0_ce	numeric parameter, probability of occurrence composite endpoint in the control group
p1_ce	numeric parameter, probability of occurrence composite endpoint in the treatment group

Value

This function returns the estimated correlation based on unblinded data and the truncated correlation within the possible margins.

eselect documentation built on Feb. 16, 2023, 8:11 p.m.