This package tests for differences in minor allele frequency between groups and is based on extra-binomial variation model for pooled sequencing data.
To use the function exbio, simply define two matrices R, R.alt with the same dimensions (rows index SNPs and columns index pools), a vector cc indicating the case and control status, number of chromosomes (n) and then do: exbio(R, R.alt, cc, n) to yield the estimated allele frequencies and p-value based on extra-binomial model.
Xin Yang, Chris Wallace
Maintainer: Xin Yang <firstname.lastname@example.org>
Yang et al. "Extra-binomial variation approach for analysis of pooled DNA sequencing data", under review.
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.