FamSKAT-RC is a family-based association kernel test for both rare and common variants. This test is general and several special cases are known as other methods: famSKAT, which only focuses on rare variants in family-based data, SKAT, which focuses on rare variants in population-based data (unrelated individuals), and SKAT-RC, which focuses on both rare and common variants in population-based data. When one applies famSKAT-RC and sets the value of phi to 1, famSKAT-RC becomes famSKAT. When one applies famSKAT-RC and set the value of phi to 1 and the kinship matrix to the identity matrix, famSKAT-RC becomes SKAT. When one applies famSKAT-RC and set the kinship matrix (fullkins) to the identity matrix (and phi is not equal to 1), famSKAT-RC becomes SKAT-RC. We also include a small sample synthetic pedigree to demonstrate the method with. For more details see Saad M and Wijsman EM (2014) <doi:10.1002/gepi.21844>.
Package details |
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Author | Khalid B. Kunji [aut, cre], Mohamad Saad [aut] |
Maintainer | Khalid B. Kunji <kkunji@hbku.edu.qa> |
License | GPL (>= 3) |
Version | 1.1.0 |
URL | https://www.r-project.org https://www.ncbi.nlm.nih.gov/pubmed/25132070 |
Package repository | View on CRAN |
Installation |
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